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ATH 686

CAS No. 853299-52-2

ATH 686( —— )

Catalog No. M20993 CAS No. 853299-52-2

ATH 686 is an potent and selective Inhibitor of FLT3.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    ATH 686
  • Note
    Research use only, not for human use.
  • Brief Description
    ATH 686 is an potent and selective Inhibitor of FLT3.
  • Description
    ATH 686 is an potent and selective Inhibitor of FLT3.
  • In Vitro
    ATH686 (1-100 μM; 3 days) potently inhibits cell proliferation (IC50 around 0.001 μM) via induction of apoptosis in FLT3-ITD-Ba/F3 cells and D835Y-Ba/F3 cells. ATH686 (10 nM; for 15 minutes) inhibits autophosphorylation of mutant FLT3 in FLT3-ITD-Ba/F3 cells. Cell Proliferation Assay Cell Line:FLT3-ITD-Ba/F3 cells and D835Y-Ba/F3 cells Concentration:1, 5, 10, 50, 100 μM Incubation Time:3 days Result:Potently inhibited cell proliferation (IC50 around 0.001 μM) via induction of apoptosis.Western Blot Analysis Cell Line:FLT3-ITD-Ba/F3 cells Concentration:10 nM Incubation Time:For 15 minutes Result:Inhibited autophosphorylation of mutant FLT3, with no apparent reduction in levels of the FLT3 protein.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Angiogenesis
  • Target
    FLT
  • Recptor
    FLT3
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    853299-52-2
  • Formula Weight
    515.53
  • Molecular Formula
    C25H28F3N7O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 250 mg/mL (484.94 mM)
  • SMILES
    CCN1CCN(Cc2ccc(NC(=O)Nc3ccc(Oc4ccnc(N)n4)cc3)cc2C(F)(F)F)CC1
  • Chemical Name
    1-[4-(2-Amino-pyrimidin-4-yloxy)-phenyl]-3-[4-(4-ethyl-piperazin-1-ylmethyl)-3-trifluoromethyl-phenyl]-urea

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Weisberg E Roesel J Furet P Bold G Imbach P Fl?rsheimer A Caravatti GJiang J Manley P Ray A Griffin JD. Antileukemic Effects of Novel First- and Second-Generation FLT3 Inhibitors: Structure-Affinity Comparison. Genes Cancer.2010 Oct;1(10):1021-32.
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